Pittsburgh EMS, Fire, and Police responded to the 600 block of N Murtland Avenue around 11:45 a.m. for a reported structure fire.
When firefighters arrived on scene, they observed heavy smoke coming from the top two floors of the row home.
A male and female on the first floor of the duplex were able to escape without injuries.
First responders learned the top apartment was a vacant unit. Two nearby homes sustained minor damage.
The 2-alarm fire was contained shortly after noon, and there were no injuries.
The Fire Investigation Unit are looking into the cause.