Pittsburgh Police from Zone 5, Pittsburgh Bureau of Fire, and EMS responded to a two-vehicle collision at the intersection of Brushton Avenue and Hamilton Avenue just before 1:30 a.m.
Arriving police units, Engine 17, and Medic 19 aided a female passenger who was ejected from one of the vehicles.
The victim was transported to the hospital in critical condition, where she was later pronounced deceased.
The Collision Investigation Unit processed the scene.
The investigation is ongoing.