Zone 4 Police, EMS, and Fire responded for a two-vehicle, head-on collision on Mifflin Road just past Mooney Road around 1:35 p.m.
Responding units located one vehicle with an injured male and female inside. Medics transported them both in critical condition.
A male driver, the sole occupant of the other vehicle, was transported to the hospital in stable condition.
It's believed one of the vehicles lost control on the icy roadway and veered into the opposing lane.
The Collision Investigation Unit is investigating.