Pittsburgh Bureau of Fire responded to a 9-1-1 call of a structure fire on the 500 block of Shelbourne Avenue in Wilkinsburg around 1:40 a.m.
When firefighters arrived, they were notified of entrapment on the second floor.
Crews made entry into the home where they located to unconscious individuals.
Both were taken to the hospital where they were pronounced deceased.
A Pittsburgh firefighter suffered an injury from a fall. He was transported in stable condition with non-life threatening injuries.
The Allegheny County Fire Marshal are handling the investigation.