Pittsburgh Police officers from Zone 6 responded to a reports of a serious collision on Saw Mill Run Blvd. near Moredale Street just after 9 a.m.
When they arrived on scene they found two-vehicles had collided head-on.
The 35-year-old female driver of the vehicle headed outbound was transported by EMS to the hospital with serious injuries.
The 60-year-old female driver of the vehicle traveling inbound was transported to Mercy Hospital where she was later pronounced deceased.
There were no passengers in either vehicle.
Witnesses at the scene told police they believed one of the drivers may have experienced a medical emergency.
The Collision Investigation Unit is working to establish the exact cause of the crash.
Tonight, the City-County Building is illuminated to recognize Poison Prevention Week and the 50th Anniversary of "Mr. Yuk" in partnership with Children's Hospital of Pittsburgh of UPMC.
For questions about the lighting at the City-County Building, please reach out to the Office of the Mayor.