Pittsburgh Police officers from Zone 5 responded to a 911 call for a person shot on the 7000 block of Monticello Street just before 2:20 a.m.
When responding officers arrived on scene, they found a female victim, an adult, inside a residence with a gunshot wound.
She was pronounced deceased by medics shortly after their arrival.
Detectives from Major Crimes and the Crime Scene Unit arrived to process the scene.
Police are searching for a male suspect. No description is available at this time.
The investigation is ongoing.