Pittsburgh Police officers from Zone 5 responded to a 911 call for a person shot on the 7000 block of Monticello Street just before 2:20 a.m.
When responding officers arrived on scene, they found a female victim, an adult, inside a residence with a gunshot wound.
She was pronounced deceased by medics shortly after their arrival.
Detectives from Major Crimes and the Crime Scene Unit arrived to process the scene.
Police are searching for a male suspect. No description is available at this time.
The investigation is ongoing.
Tonight, the City-County Building is illuminated to recognize Poison Prevention Week and the 50th Anniversary of "Mr. Yuk" in partnership with Children's Hospital of Pittsburgh of UPMC.
For questions about the lighting at the City-County Building, please reach out to the Office of the Mayor.